Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

We offer a fast-paced and collaborative work environment, with a competitive compensation and benefits package, including equity grants and the opportunity to participate in our employee stock purchase plan. We foster an environment that is supportive and fun – enabling us to bring our best each day toward achieving our goals. Working together, we’ll succeed.

We are centrally located in Boston’s Back Bay neighborhood, easily accessible by several modes of public transportation and walking distance to much of what the city has to offer.

We continue to grow, so if you don’t see anything here that currently fits your qualifications, please visit again to see what roles we have open.

Thank you for considering Rhythm.

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Global Accounts Payable Manager

Boston, MA

Full Time

Accounting and Finance

Experienced

Company Overview
Rhythm is a biopharmaceutical company aimed at developing and commercializing therapies for the treatment of rare genetic diseases of obesity. Working at Rhythm means that you are part of a team that is passionate about transforming the lives of people living with rare genetic diseases of obesity. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

Opportunity Overview
Rhythm Pharmaceuticals is seeking a Global Accounts Payable Manager to join our Finance and Accounting team. The Global Accounts Payable Manager is responsible for leading and optimizing the end‑to‑end accounts payable function across multiple regions and legal entities. This role ensures timely, accurate, and compliant processing of vendor payments for both the US and international entities, while driving standardization, automation, and continuous improvement across global AP operations.

Reporting to the Senior Director, Accounting & Financial Reporting, this role is a critical member of the accounting operations team, with interaction with the Corporate Controller, International Controller and many other operational stakeholders.

Responsibilities and Duties

Lead and manage global accounts payable operations across multiple countries, currencies, and entities
Oversee vendor management, invoice processing and employee reimbursements
Ownership of global payment runs and AP mailbox
Lead the travel and expense reimbursement function, including policy oversight, system administration and optimization of Concur functionality.
Ensure compliance with internal controls, SOX requirements, local statutory regulations, and company policies
Drive standardization of AP processes and controls across regions while balancing local regulatory needs
Manage and develop regional AP teams, including performance management, training, and career development
Serve as the primary escalation point for complex vendor issues, payment discrepancies, and audit inquiries
Partner with Procurement and business stakeholders to improve purchase‑to‑pay (P2P) efficiency and vendor experience
Own AP‑related month‑end and year‑end close activities, including accruals, reconciliations, and reporting
Lead AP participation in internal and external audits; ensure timely remediation of findings
Drive automation and process improvement initiatives (e.g., invoice capture, workflow tools, ERP enhancements)
Monitor and report on key performance indicators (KPIs) such as invoice cycle time, payment accuracy, invoices processed, and aging
Support global ERP implementations, system upgrades, and integrations related to AP processes
Perform other responsibilities across the accounting department as needed.

Qualifications and Skills

Bachelor’s degree in accounting or finance preferred
5+ years of progressive experience in a public-company accounts payable group; Biotech/Pharmaceutical preferred
2+ years of people management experience, preferably managing geographically dispersed teams
Ability to drive continuous improvement to optimize processes and maintain a solution-oriented mindset
Ability to work both independently and deliver on responsibilities within a highly collaborative environment
Excellent attention to detail, project management and organizational skills
Strong knowledge of AP processes, internal controls, and SOX compliance
Demonstrated ability to lead process transformation and operational scalability
Strong analytical, problem‑solving, and organizational skills
Excellent communication and stakeholder management skills
Ability to operate effectively in a fast‑paced, global environment across time zones
Proficiency in Excel
Experience working with ERP systems (Microsoft D365, Oracle Fusion, NetSuite, etc) and AP/P2P automation tools (i.e. Coupa) is preferred

This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.

The expected salary range for this position is $110,000 - $165,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.

More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.

At Rhythm, our core values are:

We are committed to advancing scientific understanding to improve patients’ lives.
We are inspired to tackle tough challenges and have the courage to ask bold questions.
We are eager to learn and adapt.
We believe collaboration and ownership are foundational for our success.
We value the unique contribution each individual brings to furthering our mission.

Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.

Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

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