Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

We offer a fast-paced and collaborative work environment, with a competitive compensation and benefits package, including equity grants and the opportunity to participate in our employee stock purchase plan. We foster an environment that is supportive and fun – enabling us to bring our best each day toward achieving our goals. Working together, we’ll succeed.

We are centrally located in Boston’s Back Bay neighborhood, easily accessible by several modes of public transportation and walking distance to much of what the city has to offer.

We continue to grow, so if you don’t see anything here that currently fits your qualifications, please visit again to see what roles we have open.

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Director, Value and Evidence

Boston, MA

Full Time

Medical Affairs

Experienced

Company Overview
Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients and their families living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases and provide meaningful support for healthcare providers and patients and their families. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

Opportunity Overview
Rhythm seeks an experienced individual to join our Medical Affairs North America team as Director, Value & Evidence. This position will serve as a strategic bridge between clinical development, regulatory and commercial roles, responsible for generating high quality evidence to maximize the value proposition of our assets across multiple indications associated with rare neuroendocrine diseases. This role requires leading the design and execution of studies with a focus on Patient Reported Outcomes (PRO)/Clinical Outcomes Assessments (COA), real world evidence generation and health economics and value dissemination. This individual will collaborate across regional teams, delivering evidence and/or tools to optimize decision making, support access and reimbursement and inform medical and clinical research protocols. This position will report to the Head of Value & Evidence (V&E).

Responsibilities and Duties

Demonstrate proven methodological and analytical expertise regarding the collection, analysis, and utilization of real-world data to provide high-quality project deliverables including abstracts, posters, and manuscripts.
Demonstrate proven expertise leading Health Economic and Outcomes Research (HEOR)/real world research in the forms of COA development and/or its validation, database analysis, observational research, PRO endpoint inclusion in product labeling and other types of HEOR research.
Proactively propose and prepare outcomes research protocols, statistical analysis plans (SAPs), and reports.
Drive longitudinal retrospective studies of existing databases to assess patient characteristics, treatment patterns, and associated clinical, economic and/or patient-reported outcomes.
Lead retrospective or prospective evaluations of disease natural history and treatment patterns, including drug utilization and adherence.
Drive cross-sectional surveys of patients, caregivers, health care providers/practitioners, and/or payers/health technology assessment authorities.
Lead clinical-economic models and assessments exploring burden of illness and/or comparative effectiveness.
Ensure findings are communicated effectively, and as appropriate in conference presentations, publications, dossiers and other means.
Create robust health technology assessment (HTA) tools to meet the evidentiary standards of regulators, HTA organizations, reimbursement authorities, third-party payers and other organizations that review evidence for formulary and access decision making.
Ensure and drive strategic alignment with internal teams including Medical Affairs, Market Access, Regulatory, Commercial, International and Clinical Development to incorporate strategic HEOR and COA needs at every stage of development program and throughout commercial availability.

Qualifications and Skills

10+ years of relevant education and experience, including time in the bio-pharmaceuticals industry, with majority of experience in PRO drug development, regulatory submissions and the commercialization process, including designing health economics and outcomes research and evidence generation independently/autonomously.
Advanced degree in epidemiology, health economics, pharmaceutical sciences, or related discipline (MS, MPH, PharmD, PhD) preferred.
Experience in rare diseases strongly preferred.
Knowledge of the drug development & commercialization process, HTA assessment methodologies, global reimbursement, US payers and regulatory requirements.
Experience in developing submissions to European-based HTA organizations.
Excellent communication, collaboration and influencing skills across internal and external stakeholders.
Well-organized with strong project management skills and ability to prioritize workload

This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.

The expected salary range for this position is $182,000 - $275,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.

More about Rhythm
We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.

At Rhythm our core values are:

We are committed to advancing scientific understanding to improve patients’ lives
We are inspired to tackle tough challenges and have the courage to ask bold questions
We are eager to learn and adapt
We believe collaboration and ownership are foundational for our success
We value the unique contribution each individual brings to furthering our mission

Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.

Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.

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